Nanotherm Therapeutics

Technology

**Confirm before treating**: Next-level predictive tissue ablation using a clinically proven 2-step image guided therapy workflow

01 — Deliver

The nanoparticles are directly injected into the tumor, where their surface coating enables targeted accumulation and retention within the tumor tissue.

02 — Confirm

Once delivered, the nanoparticle deposits remain in place and can be clearly visualized using standard imaging techniques such as CT, EBUS, or CBCT.

03 — Predict

Prior to treatment, the external energy can be adjusted with defined parameters. The goal of these adjustments is to create a predictable ablation zone that reduces unnecessary tissue damage.

Disclaimer: The Nanotherm system is an investigational device and is not approved for commercial clinical use in any jurisdiction. Any prior CE marking in the European Union has been discontinued and does not imply current regulatory authorization.

01 — Activate

A contactless and adjustable alternating magnetic field stimulates the implanted nanoparticles to heat. The energy deposited is defined only by the concentration, volume, and the magnetic field strength.

02 — Ablate

The generated heat destroys target tissue contained within a defined zone preventing collateral damage to sensitive adjacent structures.

Advantages

Nanotherm is developing a thermal ablation method to treat solid tumors: Targeted thermal ablation enabled by nanoparticle activation.

Simple clinical workflow

Treatment with the Nanotherm technology can be done one day. Our vision is to diagnose and treat patients in the same day.

Insensitive to motion

During treatment, patients breathe, their hearts beat, and they move. A tumor is literally a moving target. Nanotherm allows for stable, controlled heating over time due to contact-less energy delivery, making inaccurate real-time tumor tracking unnecessary.

Tailored to target shape

Treatment based on the individual tumor volume and localization. Nanoparticles delivered via universal 19G needle, as no antenna is needed to deliver energy, those technical restrictions are no longer a concern for the ablation zone shape.

Product Suite

The Nanotherm Technology has been demonstrated in over 200 patients.

Nanotherm^®AS1

Bioengineered non-toxic nanoparticles are placed into tumor tissue and remain in place due to their coating.

NanoActivator™

RF energy heats the nanoparticles to either directly ablate tumor cells or enhance effectiveness of conventional therapy.

Nanotherm Therapeutics in numbers

Demonstrated progress in developing and delivering advanced oncological therapies.

200+

Patients with over 1000 activations treated with NTTS

25+

Years of research, development, and clinical progress demonstrating long-term toxicology and stability.

Clinical centers conducting research

100

Patents – Strong intellectual property across key global markets

QMS

Quality Management System is ISO 13485:2016 conformal. Previously: MDR certified.

Experience Nanotherm Firsthand

Discover the future of solid tumor ablation with a personalized demo of our technology.

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